|Application ||WB, IHC-P, IF, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||67568 Da|
|Dilution||ELISA, IF, IHC-P (1:50), WB|
|Other Names||CANX, CNX, Calnexin, IP90, p90|
|Target/Specificity||Calnexin (Ab-583) Antibody detects endogenous levels of total Calnexin protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CANX / Calnexin Antibody (aa543-592) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232).|
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