|Application ||IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||48841 Da|
|Dilution||ELISA, IHC-P (1:50)|
|Other Names||HTRA2, HtrA-like serine protease, OMI, PARK13, Protease, serine, 25, PRSS25, Serine protease 25, HtrA serine peptidase 2, Serine proteinase OMI|
|Target/Specificity||HtrA2 (Ab-212) Antibody detects endogenous levels of total HtrA2 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-HTRA2 / OMI Antibody (aa181-230) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.|
|Cellular Location||Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID|
|Tissue Location||Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid|
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