Anti-PTPN11 / SHP-2 / NS1 Antibody (aa321-370)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q06124 |
Predicted | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 68011 Da |
Dilution | ELISA, IHC-P (1:50), WB |
Gene ID | 5781 |
---|---|
Alias Symbol | PTPN11 |
Other Names | PTPN11, Bptp-3, BPTP3, CFC, Csw, Corkscrew csw, Gene corkscrew, Phosphatase corkscrew, PTP-2C, SHP2, PTP-1D, PTP2C, SHP-2, SHPTP2, Noonan syndrome 1, SH-PTP2, SH-PTP3 |
Target/Specificity | SH-PTP2 Antibody detects endogenous levels of total SH-PTP2 protein. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-PTPN11 / SHP-2 / NS1 Antibody (aa321-370) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PTPN11 |
---|---|
Synonyms | PTP2C, SHPTP2 |
Function | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884). |
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Widely expressed, with highest levels in heart, brain, and skeletal muscle. |
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