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> home > Products > Primary Antibodies > Antibody Collections > Lysosome > Anti-AKR1B10 Antibody (aa1-316)
Anti-AKR1B10 Antibody (aa1-316)
Rabbit Anti Human Polyclonal Antibody
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- BACKGROUND
Application 
| WB, IHC-P, ICC |
|---|---|
| Primary Accession | O60218 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 36020 Da |
| Dilution | ICC (1:100 - 1:1000), IHC-P (10 µg/ml), WB (1:1000 - 1:10000) |
| Gene ID | 57016 |
|---|---|
| Alias Symbol | AKR1B10 |
| Other Names | AKR1B10, AKR1B11, Aldose reductase-like peptide, ALDRLn, AKR1B12, Aldose reductase-like, Aldose reductase-like 1, ARP, HARP, HSI, Small intestine reductase, ARL-1, SI reductase |
| Target/Specificity | Human AKR1B10 |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-AKR1B10 Antibody (aa1-316) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AKR1B10 |
|---|---|
| Synonyms | AKR1B11 |
| Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans- retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4- hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097). |
| Cellular Location | Lysosome. Secreted. Note=Secreted through a lysosome- mediated non-classical pathway |
| Tissue Location | Found in many tissues. Highly expressed in small intestine, colon and adrenal gland. |
Research Areas
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