Anti-HNRPA1 / HnRNP A1 Antibody (aa36-85)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P09651 |
Predicted | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 38747 Da |
Dilution | ELISA, IHC-P (1:50), WB |
Gene ID | 3178 |
---|---|
Alias Symbol | HNRNPA1 |
Other Names | HNRNPA1, HNRPA1L3, HnRNP A1, HnRNP A1-like 3, HnRNP core protein A1, Helix-destabilizing protein, HNRPA1, HnRNP core protein A1-like 3, HnRNP-A1 |
Target/Specificity | HnRNP A1 antibody detects endogenous levels of hnRNP A1. |
Reconstitution & Storage | Immunoaffinity purified |
Precautions | Anti-HNRPA1 / HnRNP A1 Antibody (aa36-85) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HNRNPA1 |
---|---|
Synonyms | HNRPA1 |
Function | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). |
Cellular Location | Nucleus. Cytoplasm Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes (PubMed:17289661) Nucleus. Note=(Microbial infection) SARS coronavirus-2/SARS-CoV-2 ORF6 protein increases accumulation to the nucleus. |
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