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Anti-TFEB Antibody (aa15-64)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19484
Predicted Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 52865 Da
Dilution ELISA, IHC-P (1:50), WB
Additional Information
Gene ID 7942
Alias Symbol TFEB
Other Names TFEB, ALPHATFEB, BHLHE35, T-cell transcription factor EB, TCFEB, Transcription factor EB
Target/Specificity TFEB Antibodyantibody detects endogenous levels of TFEB.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-TFEB Antibody (aa15-64) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms BHLHE35
Function Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
Cellular Location Cytoplasm. Nucleus. Note=Mainly present in the cytoplasm. Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus
Research Areas
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$ 450.00
Cat# ALS18059
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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