|Application ||WB, IHC-P, E|
|Calculated MW||52865 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||TFEB, ALPHATFEB, BHLHE35, T-cell transcription factor EB, TCFEB, Transcription factor EB|
|Target/Specificity||TFEB Antibodyantibody detects endogenous levels of TFEB.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-TFEB Antibody (aa15-64) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.|
|Cellular Location||Cytoplasm. Nucleus Note=Mainly present in the cytoplasm (PubMed:23434374). Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus (PubMed:23434374). In macrophages, translocates into the nucleus upon live S.enterica infection (PubMed:27184844).|
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