|Application ||IHC-P, IF, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||64507 Da|
|Dilution||ELISA, IF, IHC-P (1:50)|
|Other Names||FZD5, C2orf31, DKFZP434E2135, Frizzled family receptor 5, Fz5, Fzd-5, FzE5, Frizzled 5, Frizzled-5, Wnt receptor, Fz-5, HFZ5|
|Target/Specificity||FZD5 Antibody detects endogenous levels of total FZD5 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-FZD5 / Frizzled 5 Antibody (aa31-80) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein Note=Localized at the plasma membrane and also found at the Golgi|
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