|Application ||IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||163374 Da|
|Dilution||ELISA, IHC-P (1:50)|
|Other Names||ATP7A, Copper pump 1, Menkes disease ATPase, MNK, MK, SMAX3, Menkes syndrome, OHS, Copper-transporting ATPase 1, DSMAX, MC1|
|Target/Specificity||ATP7A antibody detects endogenous levels of ATP7A.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-MNK / ATP7A Antibody (aa591-640) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Cycles constitutively between the trans- Golgi network (TGN) and the plasma membrane. Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels Isoform 5: Endoplasmic reticulum.|
|Tissue Location||Found in most tissues except liver. Isoform 3 is widely expressed including in liver cell lines. Isoform 1 is expressed in fibroblasts, choriocarcinoma, colon carcinoma and neuroblastoma cell lines. Isoform 2 is expressed in fibroblasts, colon carcinoma and neuroblastoma cell lines|
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