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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-NIP3 / BNIP3 Antibody (aa47-96)   

Anti-NIP3 / BNIP3 Antibody (aa47-96)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q12983
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 21541 Da
Dilution ELISA, IHC-P (1:50), WB
Additional Information
Gene ID 664
Alias Symbol BNIP3
Other Names BNIP3, NIP3
Target/Specificity BNIP-3 antibody detects endogenous levels of BNIP-3.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-NIP3 / BNIP3 Antibody (aa47-96) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BNIP3
Synonyms NIP3
Function Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Cellular Location Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19- kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria Colocalizes with SPATA18 at the mitochondrion outer membrane
Research Areas
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$ 450.00
Cat# ALS18090
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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