|Application ||IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||38256 Da|
|Dilution||ELISA, IHC-P (1:50)|
|Other Names||B3GAT1, CD57, CD57 antigen, GlcAT-P, GLCUATP, Glucuronosyltransferase P, HNK-1, HNK1, LEU7, GLCATP, NK-1, NK1, LEU7 antigen, GlcUAT-P|
|Target/Specificity||CD57 antibody detects endogenous levels of CD57.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CD57 / HNK1 Antibody (aa35-84) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group (By similarity).|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Mainly expressed in the brain.|
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