|Application ||WB, IHC-P, IF|
|Predicted||Human, Mouse, Rat|
|Calculated MW||67827 Da|
|Dilution||IF, IHC-P (1:200), WB (1:500 - 1:2000)|
|Other Names||NFE2L2, NF-E2-related factor 2, NFE2-related factor 2, NRF2|
|Target/Specificity||Human NFE2L2 / NRF2|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-NFE2L2 / NRF2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents|
|Tissue Location||Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle|
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