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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-FGR Antibody (clone 3G10)   

Anti-FGR Antibody (clone 3G10)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P09769
Predicted Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG2a,k
Clone Names 3G10
Calculated MW 59479 Da
Dilution ELISA, IHC-P (10 µg/ml), WB
Additional Information
Gene ID 2268
Alias Symbol FGR
Other Names FGR, C-fgr protooncogene, C-src2, C-fgr, Fgr kinase, Fgr oncogene, p55-Fgr, p58-Fgr, p58c-fgr, Proto-oncogene c-Fgr, Tyrosine-protein kinase Fgr, p55c-fgr, SRC2, C-src-2 proto-oncogene, Fgr proto oncogene, p55-c-fgr protein
Target/Specificity Human FGR
Reconstitution & Storage Protein A purified
PrecautionsAnti-FGR Antibody (clone 3G10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGR
Synonyms SRC2
Function Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK- dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton Mitochondrion inner membrane. Mitochondrion intermembrane space. Note=Detected in mitochondrial intermembrane space and at inner membranes (By similarity) Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts.
Tissue Location Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.
Research Areas
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$ 450.00
Cat# ALS18150
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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