|Application ||WB, IHC-P, IHC-F, E|
|Calculated MW||93314 Da|
|Dilution||ELISA, IHC-Fr (1:200 - 1:500), IHC-P (15 µg/ml), WB (1:1000)|
|Other Names||POSTN, OSF2, PDLPOSTN, Periostin isoform thy6, Periostin isoform thy8, RP11-412K4.1, OSF-2, Osteoblast-specific factor 2, Periostin, Periostin isoform thy2, Periostin isoform thy4, PN|
|Target/Specificity||Recognizes human and mouse periostin|
|Precautions||Anti-POSTN / Periostin Antibody (clone Stiny-1, Biotin) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.|
|Cellular Location||Golgi apparatus. Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi.|
|Tissue Location||Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor Overexpressed in breast cancers.|
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