|Application ||WB, IHC-P, IF, ICC, IP|
|Predicted||Human, Guinea Pig|
|Calculated MW||168142 Da|
|Dilution||ICC (1 µg/ml), IF (1 µg/ml), IHC-P (5 µg/ml), IP, WB|
|Other Names||CFTR, ABC35, ABCC7, CF, DJ760C5.1, MRP7, CFTR/MRP, TNR-CFTR|
|Target/Specificity||The antibody detects cystic fibrosis transmembrane conductance factor (CFTR) from cells overexpressing the human protein. It has been successfully used in immunocytochemistry procedures. Immunocytochemical staining of HEK293 cells overexpressing huma ...|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CFTR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.|
|Cellular Location||Early endosome membrane; Multi-pass membrane protein. Cell membrane. Note=In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia.|
|Tissue Location||Expressed in the respiratory airway, including bronchial epithelium, and in the female reproductive tract, including oviduct (at protein level)|
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