|Application ||WB, IHC-P, E|
|Calculated MW||39731 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB|
|Other Names||PON1, A-esterase 1, Aromatic esterase 1, Esterase A, ESA, K-45, MVCD5, Paraoxonase 1, PON 1, Serum aryldialkylphosphatase 1, Arylesterase B-type, Paraoxonase B-type, PON, Serum aryldiakylphosphatase|
|Target/Specificity||Human PON1 / ESA|
|Reconstitution & Storage||Caprylic acid and ammonium sulfate precipitation|
|Precautions||Anti-PON1 / ESA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas|
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