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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-NPC / NPC1 Antibody (clone 4H2)   

Anti-NPC / NPC1 Antibody (clone 4H2)

Mouse Anti Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15118
Predicted Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a,k
Clone Names 4H2
Calculated MW 142167 Da
Dilution ELISA, IHC-P (10 µg/ml), WB
Additional Information
Gene ID 4864
Alias Symbol NPC1
Other Names NPC1, NPC, Niemann-Pick C1 protein, Niemann-Pick disease, type C1
Target/Specificity Human NPC / NPC1
Reconstitution & Storage Protein A purified
PrecautionsAnti-NPC / NPC1 Antibody (clone 4H2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPC1
Function Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals.
Cellular Location Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein
Research Areas
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$ 450.00
Cat# ALS18228
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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