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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-CD19 Antibody (C-Terminus)
Anti-CD19 Antibody (C-Terminus)
Goat Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P15391 |
| Predicted | Human, Mouse, Rat, Monkey, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 61128 Da |
| Dilution | IHC-P (5 µg/ml), WB (1:500 - 1:2000) |
| Gene ID | 930 |
|---|---|
| Alias Symbol | CD19 |
| Other Names | CD19, B-lymphocyte antigen CD19, CD19 molecule, Differentiation antigen CD19, T-cell surface antigen Leu-12, B4, CD19 antigen, CVID3 |
| Target/Specificity | Using spleen and Jurkat cell lysates detects a 95 kDa band by Western blot. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-CD19 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD19 |
|---|---|
| Function | Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:2463100, PubMed:1373518, PubMed:16672701). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:9382888, PubMed:9317126, PubMed:12387743, PubMed:16672701). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:2463100, PubMed:1373518). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:9317126, PubMed:12387743, PubMed:16672701). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Membrane raft {ECO:0000250|UniProtKB:P25918}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P25918} |
| Tissue Location | Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100). Detected on blood B cells (at protein level) (PubMed:2463100, PubMed:16672701) |
Research Areas
Citations (0)
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$ 467.50
Cat# ALS18239
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