|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||79677 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB (1 - 2 µg/ml)|
|Other Names||GAS6, AXLLG, AXL stimulatory factor, AXSF, GAS-6, Growth arrest-specific 6|
|Target/Specificity||GAS6 antibody is human, mouse and rat reactive. At least four isoforms of GAS6 are known to exist; this antibody will only detect the longest isoform.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-GAS6 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.|
|Tissue Location||Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen|
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