|Application ||WB, IHC-P|
|Calculated MW||27525 Da|
|Dilution||IHC-P (5 µg/ml), WB (1:1000 - 1:10000)|
|Other Names||KLK7, HK7, Kallikrein-related peptidase 7, HSCCE, Kallikrein 7, Kallikrein-7, PRSS6, Serine protease 6, SCCE, Signal protein|
|Target/Specificity||Human KLK7 / Kallikrein 7|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-KLK7 / Kallikrein 7 Antibody (aa1-253) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6- Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|- Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.|
|Cellular Location||Secreted. Note=In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front|
|Tissue Location||Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.