|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat, Monkey, Chimpanzee, Bovine, Horse, Dog|
|Calculated MW||52441 Da|
|Dilution||IHC-P (5 µg/ml), WB (0.5 µg/ml)|
|Other Names||MECP2, AUTSX3, Methyl-CpG-binding protein 2, MRX16, MRX79, MRXSL, RTT, RTS, MeCp-2 protein, RS, MRXS13, PPMX|
|Target/Specificity||The antibody detects methyl CpG binding protein 2 (MeCP2) from human, mouse and rat cells and tissues. It has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~56 kD protein representing MeCP2 from AtT20 ce ...|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-MECP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).|
|Cellular Location||Nucleus. Note=Colocalized with methyl-CpG in the genome|
|Tissue Location||Present in all adult somatic tissues tested.|
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