Anti-ACVR1C / ALK7 Antibody
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | Q8NER5 |
Predicted | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 54871 Da |
Dilution | IHC-P (1:67), WB (1:500 - 1:2000) |
Gene ID | 130399 |
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Alias Symbol | ACVR1C |
Other Names | ACVR1C, Activin receptor-like kinase 7, ACTR-IC, Activin receptor type IC, ACVRLK7, Activin receptor type-1C, ALK7, Activin A receptor, type IC, ALK-7 |
Target/Specificity | Human ACVR1C / ALK7 |
Reconstitution & Storage | Affinity purified |
Precautions | Anti-ACVR1C / ALK7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ACVR1C (HGNC:18123) |
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Function | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. |
Cellular Location | Membrane; Single- pass type I membrane protein |
Tissue Location | Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. |
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