|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||54871 Da|
|Dilution||IHC-P (1:67), WB (1:500 - 1:2000)|
|Other Names||ACVR1C, Activin receptor-like kinase 7, ACTR-IC, Activin receptor type IC, ACVRLK7, Activin receptor type-1C, ALK7, Activin A receptor, type IC, ALK-7|
|Target/Specificity||Human ACVR1C / ALK7|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-ACVR1C / ALK7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy|
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