|Application ||WB, IHC-P, E|
|Calculated MW||47668 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB|
|Other Names||KCNJ5, CIR, GIRK-4, KATP1, Heart KATP channel, IRK-4, KATP-1, KIR3.4, LQT13, Cardiac inward rectifier, GIRK4|
|Target/Specificity||Human KCNJ5 / Kir3.4 / GIRK4|
|Reconstitution & Storage||Protein A purified|
|Precautions||Anti-KCNJ5 / Kir3.4 / GIRK4 Antibody (clone 8D2) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Islets, exocrine pancreas and heart. Expressed in the adrenal cortex, particularly the zona glomerulosa|
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