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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-NEI3 / NEIL3 Antibody (aa491-540)   

Anti-NEI3 / NEIL3 Antibody (aa491-540)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TAT5
Predicted Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 67769 Da
Dilution ELISA, IHC-P (1:50), WB
Additional Information
Gene ID 55247
Alias Symbol NEIL3
Other Names NEIL3, DNA glycosylase/AP lyase Neil3, FGP2, DNA glycosylase FPG2, DNA glycosylase hFPG2, FPG2, HFPG2, Endonuclease 8-like 3, Endonuclease VIII-like 3, HNEI3, Nei-like protein 3, NEI3
Target/Specificity NEIL3 Antibody detects endogenous levels of total NEIL3 protein.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-NEI3 / NEIL3 Antibody (aa491-540) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEIL3
Function DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5- OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.
Cellular Location Nucleus.
Tissue Location Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts.
Research Areas
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$ 450.00
Cat# ALS18360
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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