|Application ||WB, IHC-P, IP|
|Predicted||Human, Mouse, Rat|
|Calculated MW||59853 Da|
|Dilution||IHC-P (1:100), IP (1:10 - 1:100), WB (1:500 - 1:1000)|
|Other Names||CYP4F2, CYPIVF2, Cytochrome P450 4F2, Cytochrome P450-LTB-omega, CPF2|
|Target/Specificity||Recognizes endogenous levels of Cytochrome P450 4F2 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CYP4F2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene- B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565).|
|Cellular Location||Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein|
|Tissue Location||Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572).|
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