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> home > Products > Primary Antibodies > Antibody Collections > mRNA processing > Anti-SRSF3 / SRP20 Antibody (C-Terminus)
Anti-SRSF3 / SRP20 Antibody (C-Terminus)
Rabbit Anti Human Polyclonal Antibody
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Application 
| WB, IHC-P, IF, ICC |
|---|---|
| Primary Accession | P84103 |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 19330 Da |
| Dilution | ICC (1:100 - 1:500), IF, IHC-P (1:100), WB (1:500 - 1:1000) |
| Gene ID | 6428 |
|---|---|
| Alias Symbol | SRSF3 |
| Other Names | SRSF3, SRp20, Pre-mRNA-splicing factor SRP20, SFRS3 |
| Target/Specificity | Recognizes endogenous levels of SRSF3 protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-SRSF3 / SRP20 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SRSF3 |
|---|---|
| Synonyms | SFRS3, SRP20 |
| Function | Splicing factor, which binds the consensus motif 5'- C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:32440474, PubMed:17036044, PubMed:26876937). Interaction with YTHDC1, a RNA- binding protein that recognizes and binds N6-methyladenosine (m6A)- containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A- containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). |
| Cellular Location | Nucleus. Nucleus speckle. Cytoplasm. Note=Recruited to nuclear speckles following interaction with YTHDC1. |
Research Areas
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