Anti-MDM4 / MDMX Antibody (clone 3B9)
Mouse Anti Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF |
---|---|
Primary Accession | O15151 |
Predicted | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2b |
Clone Names | 3B9 |
Calculated MW | 54864 Da |
Dilution | IF (1:100), IHC-P (1:50), WB (1:2000) |
Gene ID | 4194 |
---|---|
Alias Symbol | MDM4 |
Other Names | MDM4, Mdm2-like p53-binding protein, MDMX, HDMX, MRP1, p53-binding protein Mdm4, Protein Mdm4, Double minute 4 protein, MDM4-related protein 1, Protein Mdmx |
Target/Specificity | Human MDM4 / MDMX |
Reconstitution & Storage | Protein A/G purified |
Precautions | Anti-MDM4 / MDMX Antibody (clone 3B9) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MDM4 |
---|---|
Synonyms | MDMX |
Function | Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. |
Cellular Location | Nucleus. |
Tissue Location | Expressed in all tissues tested with high levels in thymus |
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