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Anti-MARCH1 Antibody (Internal)

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TCQ1
Predicted Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 32308 Da
Dilution IHC-P (1:100), WB (1:500 - 1:1000)
Additional Information
Gene ID 55016
Alias Symbol MARCH1
Other Names MARCH1, MARCH-I, RING finger protein 171, RNF171
Target/Specificity Recognizes endogenous levels of 42064 protein.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-MARCH1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RNF171
Function E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.
Cellular Location Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells.
Research Areas
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$ 395.00
Cat# ALS18484
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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