|Application ||WB, IHC-P, E|
|Calculated MW||10366 Da|
|Dilution||ELISA, IHC-P (7.5 µg/ml), WB|
|Other Names||DYNLL1, 8 kDa dynein light chain, DLC8, Dynein light chain LC8-type 1, DNCL1, DNCLC1, PIN, LC8a, Hdlc1, LC8|
|Target/Specificity||Human DYNLL1 / PIN|
|Reconstitution & Storage||Caprylic acid and ammonium sulfate precipitation|
|Precautions||Anti-DYNLL1 / PIN Antibody (aa1-89) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DLC1, DNCL1, DNCLC1, HDLC1|
|Function||Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.|
|Cellular Location||Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria|
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