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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-EED Antibody   

Anti-EED Antibody

Rabbit Anti Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75530
Predicted Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 50198 Da
Dilution IHC-P (1:100), WB
Additional Information
Gene ID 8726
Alias Symbol EED
Other Names EED, Embryonic ectoderm development, HEED, WAIT1, WAIT-1, Polycomb protein EED
Target/Specificity Human EED
Reconstitution & Storage Affinity purified
PrecautionsAnti-EED Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EED
Function Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Cellular Location Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes
Tissue Location Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer
Research Areas
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$ 395.00
Cat# ALS18600
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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