|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||21541 Da|
|Dilution||IHC-P (1:100), WB|
|Other Names||BNIP3, NIP3|
|Target/Specificity||Human NIP3 / BNIP3|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-NIP3 / BNIP3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.|
|Cellular Location||Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19- kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria Colocalizes with SPATA18 at the mitochondrion outer membrane|
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