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CLIC4 Antibody

Unpurified Mouse Monoclonal Antibody (Mab)

  • WB - CLIC4 Antibody AM1125a
    Western blot analysis of anti-CLIC4 Monoclonal Antibody (Cat.#AM1125a) in Hela cell line lysates. CLIC4(arrow) was detected using the ascites Mab.
  • IHC-P - CLIC4 Antibody AM1125a
    Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with CLIC4 Antibody (Cat.#AM1125a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y696
Other Accession NP_039234
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1κ
Clone Names 17CT9.2.8
Calculated MW 28772 Da
Additional Information
Gene ID 25932
Other Names Chloride intracellular channel protein 4, Intracellular chloride ion channel protein p64H1, CLIC4
Target/Specificity Purified His-tagged CLIC4 protein was used to produced this monoclonal antibody.
Dilution WB~~1:2000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLIC4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLIC4
Function Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus matrix. Cell membrane; Single-pass membrane protein. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles
Tissue Location Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle
Research Areas
Citations (0)

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Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).


Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Mutation detection in candidate genes for benign familial infantile seizures on a novel locus. Li N, et al. Int J Neurosci, 2010 Mar. PMID 20374090. Spatiotemporal regulation of chloride intracellular channel protein CLIC4 by RhoA. Ponsioen B, et al. Mol Biol Cell, 2009 Nov. PMID 19776349. S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4. Spiekerkoetter E, et al. Circ Res, 2009 Sep 25. PMID 19713532. CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer. Yao Q, et al. Oncol Rep, 2009 Sep. PMID 19639201.

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$ 295.00
Cat# AM1125a
(40 western blots)
Availability: In Stock
Bulk Size
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