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MMP14 Antibody (C-term)

Mouse Monoclonal Antibody (Mab)

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  • WB - MMP14 Antibody (C-term) AM1832a
    Anti-MMP14 Antibody (C-term) at 1:1000 dilution + HT-1080 whole cell lysates Lysates/proteins at 20 μg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 66 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - MMP14 Antibody (C-term) AM1832a
    Anti-MMP14 Antibody (C-term) at 1:500 dilution + A2058 whole cell lysates Lysates/proteins at 20 μg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 66 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - MMP14 Antibody (C-term) AM1832a
    MMP14 Monoclonal Antibody (C-term) (Cat. #AM1832a) western blot analysis in A2058 cell line lysates (35μg/lane).This demonstrates the MMP14 antibody detected the MMP14 protein (arrow).(8μg/ml)
  • IF - MMP14 Antibody (C-term) AM1832a
    Confocal immunofluorescent analysis of MMP14 Antibody (C-term) (Cat#AM1832a) with HepG2 cell followed by Alexa Fluor® 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P50281
Other Accession Q10739, Q95220, Q9XT90, P53690, Q9GLE4, NP_004986.1
Reactivity Human
Predicted Mouse, Rat, Rabbit, Pig, Bovine
Host Mouse
Clonality Monoclonal
Isotype Mouse IgM
Clone Names 133CT15.10.5.1
Calculated MW 65894 Da
Antigen Region 470-499 aa
Additional Information
Gene ID 4323
Other Names Matrix metalloproteinase-14, MMP-14, MMP-X1, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, MMP14
Target/Specificity This MMP14 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 470-499 amino acids from the C-terminal region of human MMP14.
Dilution WB~~1:100~500
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMMP14 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP14
Function Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2.
Cellular Location Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm
Tissue Location Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors
Research Areas
Citations (0)

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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.


Onimaru, M., et al. Arterioscler. Thromb. Vasc. Biol. 30(4):818-826(2010)
Wipff, J., et al. J. Rheumatol. 37(3):599-602(2010)
Liao, M.C., et al. Biochemistry 49(6):1127-1136(2010)

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$ 295.00
$ 99.00
Cat# AM1832a
(40 western blots)
Availability: In Stock
Bulk Size
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