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YEATS4 Antibody

Mouse Monoclonal Antibody (Mab)

  • WB - YEATS4 Antibody AM1885b
    YEATS4 antibody (Cat. #AM1885b) western blot analysis in 293 cell line lysates (35μg/lane).This demonstrates the YEATS4 antibody detected the YEATS4 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95619
Other Accession NP_006521.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,K
Clone Names 204CT4.7.2
Calculated MW 26499 Da
Additional Information
Gene ID 8089
Other Names YEATS domain-containing protein 4, Glioma-amplified sequence 41, Gas41, NuMA-binding protein 1, NuBI-1, NuBI1, YEATS4, GAS41
Target/Specificity This YEATS4 monoclonal antibody is generated from mouse immunized with YEATS4 recombinant protein.
Dilution WB~~1:100~250
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsYEATS4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms GAS41
Function Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00376, ECO:0000269|PubMed:10913114}
Tissue Location Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle
Citations (0)

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The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors.


Heisel, S., et al. BMC Mol. Biol. 11, 53 (2010) :
Turner, S.T., et al. Hypertension 52(2):359-365(2008)
Italiano, A., et al. Int. J. Cancer 122(10):2233-2241(2008)
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Park, J.H., et al. Mol. Cell. Biol. 26(11):4006-4016(2006)

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Cat# AM1885b
(40 western blots)
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