|Application ||WB, E|
|Other Accession||NP_150639.1, NP_653288.1|
|Calculated MW||120173 Da|
|Other Names||NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide, NLRP12, NALP12, PYPAF7, RNO|
|Target/Specificity||This NLRP12 monoclonal antibody is generated from mouse immunized with NLRP12 recombinant protein.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NLRP12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NALP12, PYPAF7, RNO|
|Function||May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.|
|Tissue Location||Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined.
Bailey, S.D., et al. Diabetes Care (2010) In press : Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Fahy, R.J., et al. Am. J. Respir. Crit. Care Med. 177(9):983-988(2008) Jeru, I., et al. Proc. Natl. Acad. Sci. U.S.A. 105(5):1614-1619(2008)
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