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ATG4B AntibodyMouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AM1902b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AM1902b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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ATG4B Antibody - Product info | |
| Application | WB
|
| Primary Accession | Q9Y4P1 |
| Other Accession | NP_037457.3 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | IgM,Ig? |
| Clone Names | 231CT21.1.7 |
| Calculated MW | 44294 Da |
ATG4B Antibody - Additional info | |
| Gene ID 23192 | |
| Other Names ATG4B; APG4B; AUTL1; KIAA0943; Cysteine protease ATG4B; AUT-like 1 cysteine endopeptidase; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B | |
| Target/Specificity This ATG4B monoclonal antibody is generated from mouse immunized with ATG4B recombinant protein. | |
| Dilution WB~~1:100~250 | |
| Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ATG4B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
ATG4B Antibody - Protein Information | |
| Name ATG4B | |
| Synonyms APG4B, AUTL1, KIAA0943 | |
| Function Cysteine protease required for autophagy, which cleaves the C-terminal part of MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Also mediates the lipid deconjugation required for target recycling | |
| Cellular Location Cytoplasm (Probable). | |
| Tissue Location Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas | |
ATG4B Antibody - Related products
AP1809a: ATG4B Antibody (N-term)
AP1809c: ATG4B Antibody (C-term)
AP3560a: Phospho-ATG4B-S121 Antibody
AP3561a: Phospho-ATG4B-S309 Antibody
RI10455: ATG4B predesign siRNA
BP1809a: APG4B Antibody (N-term) Blocking Peptide
BP1809b: APG4B Antibody (G93) Blocking Peptide
BP1809c: APG4B Antibody (C-term) Blocking Peptide
BP1809d: APG4B Antibody (E273) Blocking Peptide
BP1809e: APG4B Antibody (E135) Blocking Peptide
BP1809f: APG4B Antibody (S309) Blocking Peptide
BP1809g: APG4B Antibody (T69) Blocking Peptide
BP1809h: APG4B Antibody (G254) Blocking Peptide
BP1809i: APG4B Antibody (S121) Blocking Peptide
ATG4B Antibody - Application data
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ATG4B/MB10290 antibody (Cat. #AM1902b) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the ATG4B/MB10290 antibody detected the ATG4B/MB10290 protein (arrow).
ATG4B Antibody - Research Areas
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BACKGROUND
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases.
REFERENCES
?Satoo, K., et al. EMBO J. 28(9):1341-1350(2009) ?Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007) ?Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) : ?Olsen, J.V., et al. Cell 127(3):635-648(2006) ?Olsen, J.V., et al. Cell 127(3):635-648(2006)
