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DPPA2 Antibody

Mouse Monoclonal Antibody (Mab)

     
  • WB - DPPA2 Antibody AM1915b
    Western blot analysis of DPPA2 (arrow) using mouse polyclonal DPPA2 Antibody (Cat. #AM1915b). 293 cell lysates (2 μg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DPPA2 gene.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q7Z7J5
Other Accession NP_620170.3
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone Names 210CT5.14.6.1
Additional Information
Other Names Developmental pluripotency-associated protein 2, Pluripotent embryonic stem cell-related gene 1 protein, DPPA2, PESCRG1
Target/Specificity This DPPA2 monoclonal antibody is generated from mouse immunized with DPPA2 recombinant protein.
Dilution WB~~1:120~500
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDPPA2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DPPA2
Synonyms PESCRG1
Function Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.
Cellular Location Nucleus.
Tissue Location Expressed in embryonic stem cells. No expression is seen in 5 months embryo, mesenchymal stem cells, embryonic fibrocytes and adult tissues EMBL; AY283672; AAP37285.1; -; mRNA EMBL; BC018070; AAH18070.1; -; mRNA CCDS; CCDS2956.1; - RefSeq; NP_620170.3; NM_138815.3 RefSeq; XP_011510746.1; XM_011512444.2 RefSeq; XP_011510747.1; XM_011512445.2 UniGene; Hs.351113; - ProteinModelPortal; Q7Z7J5; - SMR; Q7Z7J5; - BioGrid; 127407; 21 IntAct; Q7Z7J5; 17 STRING; 9606.ENSP00000417710; - iPTMnet; Q7Z7J5; - PhosphoSitePlus; Q7Z7J5; - SwissPalm; Q7Z7J5; - BioMuta; DPPA2; - DMDM; 116241341; - EPD; Q7Z7J5; - MaxQB; Q7Z7J5; - PaxDb; Q7Z7J5; - PeptideAtlas; Q7Z7J5; - PRIDE; Q7Z7J5; - ProteomicsDB; 69552; - DNASU; 151871; - Ensembl; ENST00000478945; ENSP00000417710; ENSG00000163530 GeneID; 151871; - KEGG; hsa:151871; - UCSC; uc003dxo.3; human CTD; 151871; - DisGeNET; 151871; - EuPathDB; HostDB:ENSG00000163530.4; - GeneCards; DPPA2; - HGNC; HGNC:19197; DPPA2 HPA; HPA036134; - MIM; 614445; gene neXtProt; NX_Q7Z7J5; - OpenTargets; ENSG00000163530; - PharmGKB; PA134944028; - eggNOG; ENOG410IJEN; Eukaryota eggNOG; ENOG4111ADR; LUCA GeneTree; ENSGT00390000004871; - HOGENOM; HOG000060113; - HOVERGEN; HBG095578; - InParanoid; Q7Z7J5; - OMA; TLRDWCQ; - OrthoDB; EOG091G0QL3; - PhylomeDB; Q7Z7J5; - TreeFam; TF338129; - GeneWiki; Developmental_pluripotency_associated_2; - GenomeRNAi; 151871; - PRO; PR:Q7Z7J5; - Proteomes; UP000005640; Chromosome 3 Bgee; ENSG00000163530; - CleanEx; HS_DPPA2; - Genevisible; Q7Z7J5; HS GO; GO:0005634; C:nucleus; IDA:HPA GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW InterPro; IPR025891; Dppa2/4_C_dom InterPro; IPR025892; Dppa2/4_central_dom InterPro; IPR003034; SAP_dom Pfam; PF14047; DCR; 1 Pfam; PF14049; Dppa2_A; 1 PROSITE; PS50800; SAP; 1 2: Evidence at transcript level; Complete proteome; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation CHAIN 1 298 Developmental pluripotency-associated protein 2 /FTId=PRO_0000239263 DOMAIN 92 126 SAP. {ECO:0000255|PROSITE- ProRule:PRU00186} VARIANT 131 131 R -> Q (in dbSNP:rs9809030) /FTId=VAR_028087 CONFLICT 89 89 L -> S (in Ref. 1; AAP37285) SEQUENCE 298 AA; 33784 MW; 87FBCCCF52E88B5D CRC64; MSDANLDSSK KNFLEGEVDD EESVILTLVP VKDDANMEQM EPSVSSTSDV KLEKPKKYNP GHLLQTNEQF TAPQKARCKI PALPLPTILP PINKVCRDTL RDWCQQLGLS TNGKKIEVYL RLHRHAYPEQ RQDMPEMSQE TRLQRCSRKR KAVTKRARLQ RSYEMNERAE ETNTVEVITS APGAMLASWA RIAARAVQPK ALNSCSIPVS VEAFLMQASG VRWCVVHGRL LSADTKGWVR LQFHAGQAWV PTTHRRMISL FLLPACIFPS PGIEDNMLCP DCAKRNKKMM KRLMTVEK
Research Areas
Citations (0)

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Background

DPPA2 may play a role in maintaining cell pluripotentiality.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Tchabo, N.E., et al. Cancer Immun. 9, 6 (2009) :
John, T., et al. Clin. Cancer Res. 14(11):3291-3298(2008)
Monk, M., et al. Mol. Hum. Reprod. 14(6):347-355(2008)
Du, J., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21(6):542-547(2004)

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$ 295.00
$ 99.00
Cat# AM1915b
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(40 western blots)
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