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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PTPN11 Antibody   

PTPN11 Antibody

Mouse Monoclonal Antibody (Mab)

  • WB - PTPN11 Antibody AM1920b
    PTPN11 Antibody (Cat. #AM1920b) western blot analysis in A549 cell line lysates (35μg/lane).This demonstrates the PTPN11 antibody detected the PTPN11 protein (arrow).
  • WB - PTPN11 Antibody AM1920b
    PTPN11 Antibody (Cat. #AM1920b) western blot analysis in mouse brian tissue lysates (35μg/lane).This demonstrates the PTPN11 antibody detected the PTPN11 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q06124
Other Accession NP_002825.3
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone Names 246CT9.8.2
Calculated MW 68436 Da
Additional Information
Gene ID 5781
Other Names Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, PTPN11, PTP2C, SHPTP2
Target/Specificity This PTPN11 monoclonal antibody is generated from mouse immunized with PTPN11 recombinant protein.
Dilution WB~~1:100
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPTPN11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPN11
Synonyms PTP2C, SHPTP2
Function Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
Cellular Location Cytoplasm.
Tissue Location Widely expressed, with highest levels in heart, brain, and skeletal muscle.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.


Yang, X., et al. Mol. Cell. Biol. 30(22):5306-5317(2010)
Kikkawa, N., et al. Br. J. Cancer 103(6):877-884(2010)
Meng, S., et al. J Mol Cell Biol 2(4):223-230(2010)
Demir, K., et al. Turk. J. Pediatr. 52(3):321-324(2010)
Tang, C., et al. Zhongguo Fei Ai Za Zhi 13(2):98-101(2010)

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$ 295.00
$ 99.00
Cat# AM1920b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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