|Application ||WB, E|
|Calculated MW||25631 Da|
|Other Names||Glutathione S-transferase A1, GST HA subunit 1, GST class-alpha member 1, GST-epsilon, GSTA1-1, GTH1, Glutathione S-transferase A1, N-terminally processed, GSTA1|
|Target/Specificity||This GSTA1 monoclonal antibody is generated from mouse immunized with GSTA1 recombinant protein.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GSTA1 Antibody (ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.|
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Provided below are standard protocols that you may find useful for product applications.
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.
Elhasid, R., et al. Pediatr Blood Cancer 55(6):1172-1179(2010) Hawken, S.J., et al. Hum. Genet. 128(1):89-101(2010) Oguztuzun, S., et al. Folia Histochem. Cytobiol. 48(1):122-127(2010) Eriksen, K.T., et al. J. Toxicol. Environ. Health Part A 73(9):583-595(2010) Nguyen, T.V., et al. Oncol. Res. 18(7):349-355(2010)
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