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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   C-rel Antibody   

C-rel Antibody

Mouse Monoclonal Antibody (Mab)

  • WB - C-rel Antibody AM1937b
    C-rel Antibody (Cat. #AM1937b) western blot analysis in Hela cell line lysates (35μg/lane).This demonstrates the C-rel antibody detected the C-rel protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q04864
Other Accession NP_002899.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b,k
Clone Names 318CT41.3.2
Calculated MW 68520 Da
Additional Information
Gene ID 5966
Other Names Proto-oncogene c-Rel, REL
Target/Specificity This REL monoclonal antibody is generated from mouse immunized with REL recombinant protein.
Dilution WB~~1:120~1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsC-rel Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name REL
Function Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
Cellular Location Nucleus.
Research Areas
Citations (0)

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The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed 18037997]).


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
von Vietinghoff, S., et al. J. Immunol. 185(1):670-678(2010)
Deambrogi, C., et al. Am. J. Hematol. 85(7):541-544(2010)
Potter, C., et al. Ann. Rheum. Dis. 69(7):1315-1320(2010)
Stahl, E.A., et al. Nat. Genet. 42(6):508-514(2010)

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$ 295.00
$ 99.00
Cat# AM1937b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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