- Antibodies
- New
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Tag
- Peptides
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Amino Acids
- Tag
- Biological Process >
- Proteins
- RNAi
- FL cDNA Clones
- Cell/Tissues/Lysates
Glucagon Antibody (ascites)Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
Australia Austria Belgium Brazil Bulgaria Canada China Croatia Cyprus Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland India Indonesia Ireland Israel Italy Japan Korea Latvia Lithuania Luxembourg Macedonia Malaysia Malta Netherlands Norway Pakistan Poland Portugal Romania Serbia Singapore Slovakia Slovenia Spain Sweden Switzerland Taiwan Turkey United Kingdom United States Vietnam Others 
|
|||
|---|---|---|---|---|
| Catalog # | Size | Availability | Price | |
| AM1940a | 0.1 ml 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
Glucagon Antibody (ascites) - Product info | |
| Application | WB
|
| Primary Accession | P01275 |
| Other Accession | NP_002045.1 |
| Reactivity | Human |
| Concentration | Crude ascites |
| Isotype | IgG1 |
| Clone Names | 329CT36.10.10 |
| Calculated MW | 20909 Da |
Glucagon Antibody (ascites) - Additional info | |
| Gene ID 2641 | |
| Other Names GCG; Glucagon; Glicentin; Glicentin-related polypeptide; Oxyntomodulin; Glucagon-like peptide 1; Incretin hormone; Glucagon-like peptide 1(7-37); Glucagon-like peptide 1(7-36); Glucagon-like peptide 2 | |
| Target/Specificity This GCG monoclonal antibody is generated from mouse immunized with GCG recombinant protein. | |
| Dilution WB~~1:500~8000 | |
| Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Glucagon Antibody (ascites) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Glucagon Antibody (ascites) - Protein Information | |
| Name GCG | |
| Function Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life | |
| Cellular Location Secreted. | |
| Tissue Location Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain | |
Glucagon Antibody (ascites) - Related products
AM1940a: Glucagon Antibody (ascites)
AP6515a: GCG Antibody (N-term)
AP6798c: Glucagon Antibody (C-term)
BP6515a: GCG Antibody (N-term) Blocking Peptide
BP6798c: Glucagon Antibody (C-term) Blocking Peptide
AT2172a: GCG Antibody (monoclonal) (M01)
AT2173a: GCG Antibody (monoclonal) (M02)
AJ1124a: Calreticulin Antibody
Glucagon Antibody (ascites) - Application data
-
Glucagon Antibody (Cat. #AM1940a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the Glucagon antibody detected the Glucagon protein (arrow).
Glucagon Antibody (ascites) - Research Areas
Abgent welcomes feedback from its customers.
If you have used an Abgent product and would like to share how it has performed, please click on the
"Submit Review" button and provide the requested information. Our staff will examine and post your
review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.
Thank you for your support.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
REFERENCES
Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Hare, K.J. Dan Med Bull 57 (9), B4181 (2010) : Yamaoka-Tojo, M., et al. Cardiovasc Diabetol 9, 17 (2010) : Bertenshaw, G.P., et al. J. Biol. Chem. 276(16):13248-13255(2001)
