|Application ||WB, E|
|Other Accession||NP_037448.2, NP_001177776.1|
|Calculated MW||63510 Da|
|Other Names||CCR4-NOT transcription complex subunit 4, 632-, CCR4-associated factor 4, E3 ubiquitin-protein ligase CNOT4, Potential transcriptional repressor NOT4Hp, CNOT4, NOT4|
|Target/Specificity||This CNOT4 monoclonal antibody is generated from mouse immunized with CNOT4 recombinant protein.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNOT4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292).|
|Cellular Location||Cytoplasm. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Lau, N.C., et al. Biochem. J. 422(3):443-453(2009)
Mersman, D.P., et al. Genes Dev. 23(8):951-962(2009)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Winkler, G.S., et al. J. Mol. Biol. 337(1):157-165(2004)
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