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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PGR/PR Antibody (Ascites)   

PGR/PR Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

  • WB - PGR/PR Antibody (Ascites) AM1958A
    PGR/PR Antibody (Cat. #AM1958a) western blot analysis in SK-BR-3 cell line lysates (35μg/lane).This demonstrates the PGR/PR antibody detected the PGR/PR protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06401
Other Accession NP_000917.3
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 312CT8.2.1.6
Calculated MW 98981 Da
Antigen Region 349-377 aa
Additional Information
Gene ID 5241
Other Names Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3
Target/Specificity This PGR/PR antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 349-377 amino acids from human PGR/PR.
Dilution WB~~1:100~3200
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPGR/PR Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PGR
Synonyms NR3C3
Function The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
Cellular Location Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases Isoform 4: Mitochondrion outer membrane
Research Areas
Citations (0)

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This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.


Geradts, J., et al. Cancer Invest. 28(9):969-977(2010)
Tang, P., et al. Cancer Invest. 28(9):978-982(2010)
Van Belle, V., et al. J. Clin. Oncol. 28(27):4129-4134(2010)
Taylor, K.C., et al. Horm Res Paediatr (2010) In press :
Near, A.M., et al. Fertil. Steril. (2010) In press :

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$ 295.00
Cat# AM1958A
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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