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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   UCHL1 Antibody   

UCHL1 Antibody

Mouse Monoclonal Antibody (Mab)

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  • IHC-P - UCHL1 Antibody AM1959B
    Immunohistochemical analysis of paraffin-embedded H. kidney section using UCHL1(Cat#AM1959b). AM1959b was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
  • IF - UCHL1 Antibody AM1959B
    Fluorescent image of A549 cells stained with UCHL1 Antibody(Cat#AM1959b). AM1959b was diluted at 1:25 dilution. An Alexa Fluor® 488-conjugated goat anti-mouse lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Alexa Fluor® 555 conjugated with Phalloidin (red).
  • WB - UCHL1 Antibody AM1959B
    Western blot analysis of lysates from U266, mouse Neuro-2a, rat PC-12, C6 cell line and mouse brain tissue lysate(from left to right), using UCHL1 Antibody(Cat. #AM1959b). AM1959b was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 35μg per lane.
  • WB - UCHL1 Antibody AM1959B
    UCHL1 Antibody(Cat. #AM1959b) western blot analysis in NCI-H460 cell line lysates (35μg/lane).This demonstrates the UCHL1 antibody detected the UCHL1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P09936
Other Accession NP_004172.2
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1,k
Clone Names 346CT2.2.1
Calculated MW 24824 Da
Additional Information
Gene ID 7345
Other Names Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, 6---, Neuron cytoplasmic protein 95, PGP 95, PGP95, Ubiquitin thioesterase L1, UCHL1
Target/Specificity This UCHL1 monoclonal antibody is generated from mouse immunized with UCHL1 recombinant protein.
Dilution IHC-P~~1:25
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsUCHL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UCHL1
Function Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Cellular Location Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. Note=About 30% of total UCHL1 is associated with membranes in brain
Tissue Location Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients
Research Areas
Citations (0)

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The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.


Martins-de-Souza, D., et al. J Psychiatr Res 44(14):989-991(2010)
Hussain, S., et al. Leukemia 24(9):1641-1655(2010)
Ma, Y., et al. J. Cell. Biochem. 110(6):1512-1519(2010)
Wu, Y.R., et al. Clin. Chim. Acta 411 (13-14), 955-958 (2010) :
Li, L., et al. Clin. Cancer Res. 16(11):2949-2958(2010)

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$ 295.00
$ 99.00
Cat# AM1959B
(40 western blots)
Availability: In Stock
Bulk Size
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