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KEAP1 Antibody

Mouse Monoclonal Antibody (Mab)

  • WB - KEAP1 Antibody AM1968b
    KEAP1 Antibody (Cat. #AM1968b) western blot analysis in MDA-MB231 cell line lysates (35μg/lane).This demonstrates the KEAP1 antibody detected the KEAP1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14145
Other Accession Q684M4, NP_036421.2, NP_987096.1
Reactivity Human
Predicted Pig
Host Mouse
Clonality Monoclonal
Isotype IgM,k
Clone Names 297CT6.1.6
Calculated MW 69666 Da
Antigen Region 422-449 aa
Additional Information
Gene ID 9817
Other Names Kelch-like ECH-associated protein 1, Cytosolic inhibitor of Nrf2, INrf2, Kelch-like protein 19, KEAP1, INRF2, KIAA0132, KLHL19
Target/Specificity This KEAP1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 422-449 amino acids from human KEAP1.
Dilution WB~~1:100
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKEAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KEAP1
Synonyms INRF2, KIAA0132, KLHL19
Function Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus
Tissue Location Broadly expressed, with highest levels in skeletal muscle.
Citations (0)

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This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.


Dinkova-Kostova, A.T., et al. J. Biol. Chem. 285(44):33747-33755(2010)
Kang, H.J., et al. J. Biol. Chem. 285(28):21258-21268(2010)
Lau, A., et al. Mol. Cell. Biol. 30(13):3275-3285(2010)
Copple, I.M., et al. J. Biol. Chem. 285(22):16782-16788(2010)
Takahashi, T., et al. J Surg Oncol 101(6):500-506(2010)

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$ 295.00
$ 99.00
Cat# AM1968b
(40 western blots)
Availability: In Stock
Bulk Size
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