|Application ||WB, E|
|Other Accession||NP_001172027.1, NP_001172026.1|
|Calculated MW||11981 Da|
|Antigen Region||35-64 aa|
|Other Names||Insulin, Insulin B chain, Insulin A chain, INS|
|Target/Specificity||This INS antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 35-64 amino acids from human INS.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||INS Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|
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Provided below are standard protocols that you may find useful for product applications.
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
Hinks, A., et al. Ann. Rheum. Dis. 69(12):2169-2172(2010)
Breuer, T.G., et al. Eur. J. Endocrinol. 163(4):551-558(2010)
Andersen, M.K., et al. Diabetes Care 33(9):2062-2064(2010)
Ferron, M., et al. Cell 142(2):296-308(2010)
Authier, F., et al. J. Biol. Chem. 277(11):9437-9446(2002)
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