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ZWINT Antibody(Ascites)

Mouse Monoclonal Antibody (Mab)

  • WB - ZWINT Antibody(Ascites) AM2010a
    ZWINT Antibody (Cat. #AM2010a) western blot analysis in mouse cerebellum tissue lysates (35μg/lane).This demonstrates the ZWINT antibody detected the ZWINT protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95229
Other Accession NP_008988.2, NP_001005413.1
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 422CT4.6.4
Calculated MW 31293 Da
Additional Information
Gene ID 11130
Other Names ZW10 interactor, ZW10-interacting protein 1, Zwint-1, ZWINT
Target/Specificity Purified His-tagged ZWINT protein(Fragment) was used to produced this monoclonal antibody.
Dilution WB~~1:500~4000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZWINT Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.
Cellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase
Research Areas
Citations (0)

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This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.


Brendle, A., et al. Eur. J. Cancer 45(3):435-442(2009)
Famulski, J.K., et al. J. Cell Biol. 180(3):507-520(2008)
Morgan, A.R., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (6), 762-770 (2007) :
Lin, Y.T., et al. Oncogene 25(52):6901-6914(2006)
Kops, G.J., et al. J. Cell Biol. 169(1):49-60(2005)

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$ 295.00
Cat# AM2010a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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