|Application ||WB, E|
|Other Accession||NP_057361.3, NP_899050.1|
|Calculated MW||26659 Da|
|Other Names||Ras-related protein Rab-23, RAB23|
|Target/Specificity||Purified His-tagged RAB23 protein(Fragment) was used to produced this monoclonal antibody.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAB23 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side. Cell membrane Cytoplasm. Cytoplasmic vesicle, autophagosome. Endosome membrane. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It may be involved in small GTPase mediated signal transduction and intracellular protein transportation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
Alessandri, J.L., et al. Am. J. Med. Genet. A 152A (4), 982-986 (2010) :
Hou, Q., et al. Cancer Res. 68(12):4623-4630(2008)
Ng, E.L., et al. Brain Res Rev 58(1):236-246(2008)
Jenkins, D., et al. Am. J. Hum. Genet. 80(6):1162-1170(2007)
Liu, Y.J., et al. World J. Gastroenterol. 13(7):1010-1017(2007)
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