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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   B2M Antibody (Ascites)   

B2M Antibody (Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • WB - B2M Antibody (Ascites) AM2052a
    B2M Antibody (Cat. #AM2052a) western blot analysis in CEM cell line lysates (35μg/lane).This demonstrates the B2M antibody detected the B2M protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P61769
Other Accession NP_004039.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 467CT12.3.1
Calculated MW 13715 Da
Antigen Region 10-39 aa
Additional Information
Gene ID 567
Other Names Beta-2-microglobulin, Beta-2-microglobulin form pI 53, B2M
Target/Specificity This B2M antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from human B2M.
Dilution WB~~1:1000~16000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsB2M Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name B2M
Function Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Cellular Location Secreted. Cell surface. Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280). {ECO:0000269|PubMed:7554280, ECO:0000269|Ref.6}
Research Areas
Citations (0)

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Background

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rennella, E., et al. J. Mol. Biol. 401(2):286-297(2010)
Debelouchina, G.T., et al. J. Am. Chem. Soc. 132(30):10414-10423(2010)
Mumtaz, A., et al. Saudi J Kidney Dis Transpl 21(4):701-706(2010)
Guo, H.C., et al. Nature 360(6402):364-366(1992)

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$ 295.00
Cat# AM2052a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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