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TFRC AntibodyMouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AM2075b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AM2075b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
TFRC Antibody - Product info | |
| Application | WB
|
| Primary Accession | P02786 |
| Other Accession | NP_001121620.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | IgM |
| Clone Names | 514CT23.4.1 |
| Calculated MW | 84871 Da |
TFRC Antibody - Additional info | |
| Gene ID 7037 | |
| Other Names TFRC; Transferrin receptor protein 1; T9; p90; CD_antigen=CD71; Transferrin receptor protein 1, serum form | |
| Target/Specificity Purified His-tagged TFRC protein(Fragment) was used to produced this monoclonal antibody. | |
| Dilution WB~~1:100~250 | |
| Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions TFRC Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
TFRC Antibody - Protein Information | |
| Name TFRC | |
| Function Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site | |
| Cellular Location Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV | |
TFRC Antibody - Related products
AM2075a: TFRC Antibody (Ascites)
AP2949b: CD71 Antibody (C-term)
TFRC Antibody - Application data
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TFRC Antibody (Cat. #AM2075b) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the TFRC antibody detected the TFRC protein (arrow).
TFRC Antibody - Research Areas
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BACKGROUND
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010) Blonde-Cynober, F., et al. Ann. Biol. Clin. (Paris) 68(5):569-575(2010) Marsee, D.K., et al. Am. J. Clin. Pathol. 134(3):429-435(2010) Fernandez-Real, J.M., et al. Eur. J. Clin. Invest. 40(7):600-607(2010)
