|Application ||WB, E|
|Other Accession||P35448, P35441, Q28178, NP_003237.2|
|Predicted||Mouse, Xenopus, Bovine|
|Calculated MW||129383 Da|
|Antigen Region||763-789 aa|
|Other Names||Thrombospondin-1, THBS1, TSP, TSP1|
|Target/Specificity||This THBS1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 763-789 amino acids from the Central region of human THBS1.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||THBS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).|
|Cellular Location||Endoplasmic reticulum. Sarcoplasmic reticulum|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
Zhou, L., et al. Cancer Res. 70(20):8199-8210(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Nucera, C., et al. Proc. Natl. Acad. Sci. U.S.A. 107(23):10649-10654(2010)
Gustavsson, H., et al. BMC Cancer 10, 288 (2010) :
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